Selected Research Papers

 

2017

Parsonage RK, Hiscock J, Law RJ, Neal RD. Patient Perspectives on Delays in Diagnosis and Treatment of Cancer: A Qualitative Analysis of Free-text Data. Br  J  Gen Pract. 2017;67(654):e49-e56. 

Mason MD, Clarke NW, James ND, Dearnaley DP, Spears MR, Ritchie AW, et al. Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naive Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2017. 

Liu Y, Bunston C, Hodson N, Resaul J, Sun PH, Cai S, et al. Psoriasin Promotes Invasion, Aggregation and Survival of Pancreatic Cancer Cells; Association with Disease Progression. International Journal of Oncology. 2017. 

Fossati N, Willemse PM, Van den Broeck T, van den Bergh RC, Yuan CY, Briers E, et al. The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review. European Urology. 2017. 

Chen G, Yu H, Satherley L, Zabkiewicz C, Resaul J, Zhao H, et al. The Downstream of Tyrosine Kinase 7 is Reduced in Lung Cancer and is Associated with Poor Survival of Patients with Lung Cancer. Oncology  Reports. 2017.

Berthon B, Evans M, Marshall C, Palaniappan N, Cole N, Jayaprakasam V, et al. Head and Neck Target Delineation Using a Novel PET Automatic Segmentation Algorithm. Radiother Oncol. 2017;122(2):2427. 

Sun PH, Chen G, Mason M, Jiang WG, Ye L. Dual Roles of Protein Tyrosine Phosphatase Kappa in Coordinating Angiogenesis Induced by Pro-Angiogenic Factors. International Journal of Oncology. 2017;50(4):1127-35. 

Cai S, Sun PH, Resaul J, Shi L, Jiang A, Satherley LK, et al. Expression of Phospholipase C Isozymes in Human Breast Cancer and Their Clinical Significance.  Oncology Reports. 2017;37(3):1707-15.

Planells-Palop V, Hazazi A, Feichtinger J, Jezkova J, Thallinger G, Alsiwiehri NO, et al. Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Mol Cancer. 2017;16(1):84.

Berthon B, Spezi E, Galavis P, Shepherd T, Apte A, Hatt M, et al. Toward a Standard for the Evaluation of PET-Auto-Segmentation Methods Following the Recommendations of AAPM Task group No. 211: Requirements and Implementation. Medical Physics. 2017;44(8):4098-111.

Foley KG, Hills RK, Berthon B, Marshall C, Parkinson C, Lewis WG, et al. Development and Validation of a Prognostic Model Incorporating Texture Analysis Derived from Standardised Segmentation of PET in Patients with Oesophageal Cancer. Eur Radiol. 2017. 

Salimu J, Webber J, Gurney M, Al-Taei S, Clayton A, Tabi Z. Dominant Immunosuppression of Dendritic Cell Function by Prostate-Cancer-Derived Exosomes. J Extracell. Vesicles. 2017;6(1):1368823. 

Scurr M, Pembroke T, Bloom A, Roberts D, Thomson A, Smart K, et al. Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research. 2017;23(22):6771-80.

Scurr M, Pembroke T, Bloom A, Roberts D, Thomson A, Smart K, et al. Effect of Modified Vaccinia Ankara-5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial. JAMA Oncol. 2017;3(10):e172579. 

Johnson CE and Tee AR. Exploiting Cancer Vulnerabilities: mTOR, Autophagy, and Homeostatic Imbalance. Essays Biochem. 2017;61(6):699-710. 

 

2016

Zhao H, Yu H, Martin TA, Zhang Y, Chen G, Jiang WG. Effect of Junctional Adhesion Molecule-2 Expression on Cell Growth, Invasion and Migration in Human Colorectal Cancer. International Journal of Oncology. 2016;48(3):929-36.

Vale CL, Burdett S, Rydzewska LH, Albiges L, Clarke NW, Fisher D, et al. Addition of Docetaxel or Bisphosphonates to Standard of Care in Men with Localised or Metastatic, Hormone-Sensitive Prostate Cancer: A Systematic Review and Meta-analyses of Aggregate Data. Lancet Oncol. 2016;17(2):243-56.

Uusi-Kerttula H, Davies J, Coughlan L, Hulin-Curtis S, Jones R, Hanna L, et al. Pseudotyped Alphavbeta6 Integrin-targeted Adenovirus Vectors for Ovarian Cancer Therapies. Oncotarget. 2016.

Tanguay JS, Catlow C, Smith C, Barber J, Staffurth J, Kumar S, et al. High Risk of Neutropenia for Hormone-naive Prostate Cancer Patients Receiving STAMPEDE-style Upfront Docetaxel Chemotherapy in Usual Clinical Practice. Clinical Oncology (Royal College of Radiologists (Great Britain)). 2016.

Owen S, Sanders AJ, Mason MD, Jiang WG. Importance of Osteoprotegrin and Receptor Activator of Nuclear Factor KappaB in Breast Cancer Response to Hepatocyte Growth Factor and the Bone Microenvironment in vitro. International Journal of Oncology. 2016;48(3):919-28.

Orlando G, Law PJ, Palin K, Tuupanen S, Gylfe A, Hanninen UA, et al. Variation at 2q35 (PNKD and TMBIM1) Influences Colorectal Cancer Risk and Identifies a Pleiotropic Effect with Inflammatory Bowel Disease. Hum Mol Genet. 2016.

Jezkova J, Williams JS, Pinto F, Sammut SJ, Williams GT, Gollins S, et al. Brachyury Identifies a Class of Enteroendocrine Cells in Normal Human Intestinal Crypts and Colorectal cancer. Oncotarget. 2016;7(10):11478-86.

James ND, Sydes MR, Clarke NW, Mason MD, Dearnaley DP, Spears MR, et al. Addition of Docetaxel, Zoledronic Acid, or Both to First-line Long-term Hormone Therapy in Prostate Cancer (STAMPEDE): Survival Results from an Adaptive, Multiarm, Multistage, Platform Randomised Controlled Trial. Lancet. 2016;387:1163-77.

Hulin-Curtis SL, Uusi-Kerttula H, Jones R, Hanna L, Chester JD, Parker AL. Evaluation of CD46 Re-Targeted Adenoviral Vectors for Clinical Ovarian Cancer Intraperitoneal Therapy. Cancer Gene Ther. 2016.

Gomez-Escobar N, Almobadel N, Alzahrani O, Feichtinger J, Planells-Palop V, Alshehri Z, et al. Translin and Trax Differentially Regulate Telomere-Associated Transcript Homeostasis. Oncotarget. 2016.

Bianchi V, Bulek A, Fuller A, Lloyd A, Attaf M, Rizkallah PJ, et al. A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen. J Biol Chem. 2016;291(17):8951-9.

 

2015

Chowdhury R, Webber JP, Gurney M, Mason MD, Tabi Z, Clayton A. Cancer Exosomes Trigger Mesenchymal Stem Cell Differentiation into Pro-Angiogenic and Pro-Invasive Myofibroblasts. Oncotarget. 2015;6(2):715-31.

Mason MD, Parulekar WR, Sydes MR, Brundage M, Kirkbride P, Gospodarowicz M, et al. Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2015.

Salimu J, Spary LK, Al-Taei S, Clayton A, Mason MD, Staffurth J, et al. Cross-Presentation of the Oncofoetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells – a Key Role for Heat Shock Protein 70 and Receptor CD91. Cancer Immunology Research. 2015.

Scurr MJ, Brown CM, Costa Bento DF, Betts GJ, Rees BI, Hills RK, et al. Assessing the Prognostic Value of Preoperative Carcinoembryonic Antigen-Specific T-Cell Responses in Colorectal Cancer. Journal of the National Cancer Institute. 2015;107(4).

Webber J, Yeung V, Clayton A. Extracellular Vesicles as Modulators of the Cancer Microenvironment. Seminars in Cell & Developmental Biology. 2015.

Men W, Martin TA, Ruge F, Zhang N, Du P, Yang Y, et al. Expression of Claudins in Human Clear Cell Renal Cell Carcinoma. Cancer Genomics & Proteomics. 2015;12(1):1-8.

Uusi-Kerttula H, Legut M, Davies J, Jones R, Hudson E, et al. Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies. Human Gene Therapy. 2015;26(5):320-9.

Al-Tassan NA, Whiffin N, Hosking FJ, Palles C, Farrington SM, Dobbins SE, et al. A New GWAS and Meta-analysis with 1000Genomes Imputation Identifies Novel Risk Variants for Colorectal Cancer. Sci Rep. 2015;5:10442.

Brundage M, Sydes MR, Parulekar WR, Warde P, Cowan R, Bezjak A, et al. Impact of Radiotherapy When Added to Androgen-Deprivation Therapy for Locally Advanced Prostate Cancer: Long-Term Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial. Journal of Clinical Oncology. 2015;33(19):2151-7.

Smith CG, Fisher D, Harris R, Maughan TS, Phipps AI, Richman S, et al. Analyses of 7,635 Patients with Colorectal Cancer Using Independent Training and Validation Cohorts Show That rs9929218 in CDH1 Is a Prognostic Marker of Survival. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. 2015;21(15):3453-61.

Berthon B, Haggstrom I, Apte A, Beattie BJ, Kirov AS, Humm JL, et al. PETSTEP: Generation of Synthetic PET Lesions for Fast Evaluation of Segmentation Methods. Phys Med. 2015.

Carrington R, Staffurth J, Warren S, Partridge M, Hurt C, Spezi E, et al. The Effect of Dose Escalation on Gastric Toxicity When Treating Lower Oesophageal Tumours: A Radiobiological Investigation. Radiat. Oncol. 2015;10(1):236.

Uusi-Kerttula H, Hulin-Curtis S, Davies J, Parker AL. Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications. Viruses. 2015;7(11):6009-42.

James ND, Spears MR, Clarke NW, Dearnaley DP, Mason MD, Parker CC, et al. Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial. JAMA Oncol. 2015:1-10.

Berthon B, Marshall C, Holmes R, Spezi E. A Novel Phantom Technique for Evaluating the Performance of PET Auto-Segmentation Methods in Delineating Heterogeneous and Irregular Lesions. EJNMMI Phys. 2015;2(1):13.

 

2014

Spary L, Salimu J, Webber J, Clayton A, Mason M, Tabi Z. Tumour stroma-derived factors skew monocyte to dendritic cell differentiation towards CD14+ programmed death-ligand 1+ phenotype in prostate cancer. Oncoimmunology. 2014.

Wiggins HL, Wymant JM, Solfa F, Hiscox SE, Taylor KM, Westwell AD, et al. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology. 2014.

Ye L, Sun PH, Sanders AJ, Martin TA, Lane J, Mason MD, et al. Therapeutic potential of capillary morphogenesis gene 2 extracellular vWA domain in tumour related angiogenesis. International Journal of Oncology. 2014;45(4):1565-73.

Venderbosch S, Nagtegaal ID, Maughan TS, Smith CG, Cheadle JP, Fisher D, et al. Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies. Clinical Cancer Research: an official journal of the American Association for Cancer Research. 2014;20(20):5322-30.

Spary LK, Al-Taei S, Salimu J, Cook AD, Ager A, Watson HA, et al. Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation. Journal of Immunology (Baltimore, Md : 1950). 2014;192(7):3101-10.

Meyer JP, Probst KC, Westwell AD. Radiochemical synthesis of 2′-[18F]-labelled and 3′-[18F]-labelled nucleosides for positron emission tomography imaging. Journal of Labelled Compounds & Radiopharmaceuticals. 2014;57(5):333-7.

Jezkova J, Williams JS, Jones-Hutchins F, Sammut SJ, Gollins S, Cree I, et al. Brachyury regulates proliferation of cancer cells via a p27Kip1-dependent pathway. Oncotarget. 2014;5(11):3813-22.

Collins J, Noble S, Chester J, Coles B, Byrne. The assessment and impact of sarcopenia in lung cancer: a systematic literature review. BMJ Open, 2014 Jan 2;4(1).

Bryant D, Tristram A, Liloglou T, Hibbitts S, Fiander A, Powell N. Quantitative measurement of Human Papillomavirus type 16 L1/L2 DNA methylation correlates with cervical disease grade. Journal of Clinical Virology: the official publication of the Pan-American Society for Clinical Virology. 2014 Jan;59(1):24-9.

Webber JP, Spary LK, Sanders AJ, Chowdhury R, Jiang WG, Steadman R, et al. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene. 2014 Jan 20.

Jia Y, Ye L, Ji K, Zhang L, Hargest R, Ji J, et al. Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy. British Journal of Cancer. 2014 Jan 21;110(2):421-9.

Webber JP, Stone TC, Katilius E, Smith BC, Gordon B, Mason MD, et al. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan) platform. Molecular & Cellular Proteomics: MCP. 2014 Feb 6.

Berthon B, Marshall C, Evans M, Spezi E. Evaluation of advanced automatic PET segmentation methods using nonspherical thin-wall inserts. Medical Physics. 2014 Feb;41(2):022502.

Hibbitts S, Tristram A, Beer H, McRea J, Rose B, Hauke A, et al. UK population based study to predict impact of HPV vaccination. Journal of Clinical Virology: the official publication of the Pan American Society for Clinical Virology. 2014 Feb;59(2):109-14.

Scurr M, Ladell K, Besneux M, Christian A, Hockey T, Smart K, et al. Highly prevalent colorectal cancer-infiltrating LAP(+) Foxp3(-) T cells exhibit more potent immunosuppressive activity than Foxp3(+) regulatory T cells. Mucosal immunology. 2014 Mar;7(2):428-39.

 

2013

Spezi E, Leal A. Special section: selected papers from the Third European Workshop on Monte Carlo Treatment Planning (MCTP2012). Physics in Medicine and Biology. 2013 Apr 21;58(8):E01.

Marcatili S, Pettinato C, Daniels S, Lewis G, Edwards P, Fanti S, et al. Development and validation of RAYDOSE: a Geant4-based application for molecular radiotherapy. Physics in Medicine and Biology. 2013 Apr 21;58(8):2491-508.

Gwynne S, Spezi E, Sebag-Montefiore D, Mukherjee S, Miles E, Conibear J, et al. Improving radiotherapy quality assurance in clinical trials: assessment of target volume delineation of the pre-accrual benchmark case. The British Journal of Radiology. 2013 Apr;86(1024):20120398.

Du P, Ye L, Yang Y, Jiang WG. Candidate of metastasis 1 regulates in vitro growth and invasion of bladder cancer cells. International Journal of Oncology. 2013 Apr;42(4):1249-56.

Sun PH, Ye L, Mason MD, Jiang WG. Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer. Journal of Cancer Research. 2013 Jul;139(7):1129-39.

Smith CG, Naven M, Harris R, Colley J, West H, Li N, et al. Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer. Human Mutation. 2013 Jul;34(7):1026-34.

Jiang WG, Ye L, Sanders AJ, Ruge F, Kynaston HG, Ablin RJ, et al. Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain. Journal of Translational Medicine. 2013;11:269.

Feichtinger J, Larcombe L, McFarlane RJ. Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers. International Journal of Cancer. 2013 Oct 31.

Smith CG, Fisher D, Claes B, Maughan TS, Idziaszczyk S, Peuteman G, et al. Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy +/- cetuximab. Clinical Cancer Research: an official journal of the American Association for Cancer Research. 2013 Aug 1;19(15):4104-13.

Evans M, Newcombe R, Fiander A, Powell J, Rolles M, Thavaraj S, et al. Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population. BMC Cancer. 2013;13:220.

Lazaro G, Smith C, Goddard L, Jordan N, McClelland R, Barrett-Lee P, et al. Targeting focal adhesion kinase in ER+/HER2+ breast cancer improves trastuzumab response. Endocrine-Related Cancer. 2013 Oct;20(5):691-704.

Scurr M, Bloom A, Pembroke T, Srinivasan R, Brown C, Smart K, et al. Escalating regulation of 5T4-specific IFN-gamma CD4 T cells distinguishes colorectal cancer patients from healthy controls and provides a target for therapy. Cancer Immunology Research. 2013 Dec;1(6).

 

2012

Sarkar D, Shields B, Davies ML, Muller J, Wakeman JA. BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells. International Journal of Cancer. 2012 Jan 15;130(2):328-37.

Nunes C, Wong R, Mason M, Fegan C, Man S, Pepper C. Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression. Clinical Cancer Research : an official journal of the American Association for Cancer Research. 2012 Feb 1;18(3):678-87.

Shelley MD, Jones G, Cleves A, Wilt TJ, Mason MD, Kynaston HG. Intravesical gemcitabine therapy for non-muscle invasive bladder cancer (NMIBC): a systematic review. BJU international. 2012 Feb;109(4):496-505.

Ye L, Sun PH, Martin TA, Sanders AJ, Mason MD, Jiang WG. Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells. Urologic Oncology. 2012 Jun 11.

Janes S, Schmidt U, Ashour Garrido K, Ney N, Concilio S, Zekri M, et al. Heat induction of a novel Rad9 variant from a cryptic translation initiation site reduces mitotic commitment. Journal of Cell Science. 2012 Oct 1;125(Pt 19):4487-97.

Gwynne S, Spezi E, Wills L, Nixon L, Hurt C, Joseph G, et al. Toward semi-automated assessment of target volume delineation in radiotherapy trials: the SCOPE 1 pretrial test case. International Journal of Radiation Oncology, Biology, Physics. 2012 Nov 15;84(4):1037-42.

Al-Taei S, Banner R, Powell N, Evans M, Palaniappan N, Tabi Z, et al. Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy. Cancer Immunology, Immunotherapy : CII. 2013 Dec;62(12):1821-30.